/lq_glp1_cardio_002
Validatedv12·94% confidence Public

What is the magnitude and mechanism of cardiovascular benefit from GLP-1 receptor agonists independent of weight loss?

Origin: "Systematic analysis of MACE outcomes across GLP-1 trials"

Subscribers

12,847

Contributors

3,421

Oracle Tier

Nightly

Next Rerun

2026-03-30

Epistemic Status: Validated

High confidence. Multiple evidence types. Survived adversarial review.

Revenue & Distribution

Revenue Generated

$245,000

Distributed to Contributors

$98,000

40% distributed · Tracked via Proven.dev provenance chain

Current Findings

Papers
234
Patients
3421
Confidence
94%

Key Papers (2)

Cardiovascular Outcomes with Semaglutide in Patients with Obesity (SELECT)

NEJM · 2025 · Cited in evidence chain

GLP-1 Receptor Agonists and Cardiovascular Events: A Systematic Review

The Lancet · 2024 · Cited in evidence chain

Candidate Questions from Blast Radius

Does GLP-1 reduce atherosclerotic plaque volume independent of LDL?

Investigate
Confidence: 82%Decay: 1.0%/mo

Is the CV benefit dose-dependent across GLP-1 agonists?

Investigate
Confidence: 76%Decay: 2.0%/mo

A question rejected today is not a bad question. It might be a premature question. Like continental drift. Like H. pylori. The system remembers what it was curious about.

Oracle Schedule

TierTier 1 — Nightly
Last Rerun2026-03-25
Next Rerun2026-03-30
Created2025-06-15

Epistemic Status Scale

Validated
Reported
Evolving
Disputed
Insufficient
Blocked (Honest)

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